Your Urology Companion

Distal renal tubules. Aldosterone is the primary human mineralocorticoid, produced exclusively by the zona glomerulosa, the only zone of the adrenal cortex containing aldosterone synthase (CYP11B2). Campbell defines its target precisely: "Aldosterone regulates electrolyte metabolism by stimulating epithelial cells of the distal nephron to reabsorb Na⁺ and Cl⁻ while secreting H⁺ and K⁺"